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| 1885.4.10 | Kwanghyewon was established at the northern part of Hansung (now Seoul) by Dr. H. N. Allen who was dispatched from the American North Presbyterian Church on September 20, 1884. Dr. Allen was appointed as the first Superintendent of Kwanghyewon. |
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| 1885.4.23 | Kwanghyewon was renamed to Chechungwon and was inaugurated as the nation? first Western stlye hospital |
| 1894.4. | The mission team of the American North Presbyterian Church took over the operation of Chechungwon |
| 1899.4. | Chechungwon Medical School, the first medical school in Korea, was established and Dr. Oliver R. Avison was appointed as the first director. |
| 1900.5. | Mr. Louis H. Severance from Cleveland of the United States donated funds for the establishment of a new hospital |
| 1904.9.3 | A new hospital was completed at Boksunga-Gol (now Do-dong). Chechungwon was moved to a new hospital building and was renamed as Severance Hospital. |
| 1969.11.10 | Opening of the Cancer Center |
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| 1974.3.16 | The College of Dentistry Annex Hospital was approved by the government |
| 1974.5.15 | Opening of Kimpo International Airport dispensary |
| 1975.11.16 | Establishment of Medical Training Institution |
| 1983.3. | Opening of Yongdong, Inchon, Yongin and Kwangju Severance Hospitals |
| 1987.5.8 | Opening of the Rehabilitation Hospital |
| 1991.5.10 | Opening of the Cardiovascular Center |
| 1991.9.20 | Opening of the Organ Transplant Ward |
| 1994.6.8 | Opening of Severance Health Promotion Center |
| 1996.10.17 | Opening of the Eye and ENT Hospital |
| 1996.12.23 | Opening of the Diabetes Center and Allergy Clinic |
| 1998.2.27 | Opening of the I.B. Yoon Multispecialty Endoscopic Research and Training Center |
| 1999.5.2 | Opening of the Center for Child and Adolescent Health |
| 1909.7. | Chechungwon Medical School was renamed to Private Severance Medical School and was approved by the government |
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| 1914. | The first internship was started |
| 1922.4.1 | School was renamed to Severance Union Medical College |
| 1947. | School was upgraded to Severance Medical College |
| 1957.1.5 | Yonhee University and Severance Medical College were united under the name of Yonsei University |
| 1962.6.5 | A New Campus and Medical Complex were dedicated at Shinchon, Seoul and Yonsei University Medical Center was started |
| 1967.12.4 | The College of Dentistry was approved by the government |
| 1968.12.4 | The College of Nursing was approved by the government |
| 1996.4.30 | Opening of the Medical Research Center |
| 1996.10.10 | Selected as ?he most outstanding medical school in the first national survey of medical schools. |
| 1999.8.31 | Selected as BK21 ivision of Medical Sciences |
| 2000.7.1 | Cancer Metastasis Research Center was selected as (SRC Science Research Center) from Korea Science and Engineering Foundation |
| 1993.3.8 | A Patient Bill of Rights was established and proclaimed |
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| 1994.7.1 | Opening of the Yonsei Friendship Hospital in the Mongolian People Republic |
| 1995.11.1 | The name Severance was approved as a registered service mark and obtained a patent right |
| 1999.11.22 | Received the first prize of Korea Innovative Management Index in hospital service by the Korea Management Association Consultants |
| 1999.11.24 | Yonsei University Medical Center Mission and Vision Statement was proclaimed |
| 2000.3.20 | Joining ceremony of Severance Healthcare Cooperative Network was held |
| 2000.7.25 | Construction of Severance New Hospital was started |
| 2005.5.1 | Construction of Severance New Hospital was finished |
| 2007.5.2 |
Accredited by Joint Commission International |