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Physician Directory

HOME > Hospitals > Severance Hospital > Departments > Endocrinology and Metabolism > Physician Directory

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Myungshik Lee
doctor's information
Name Myungshik Lee
Department
Major Metabolism, immunology
E-mail mslee0923@yuhs.ac
Homepage
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Research

IFN-gamma/TNF-alpha synergism as the final effector in autoimmune diabetes: A key role for STAT1/IFN regulatory factor-1 pathway in pancreatic beta cell death
JOURNAL OF IMMUNOLOGY 166/7 :4481-4489,2001

IFNg sensitizes ME-180 human cervical cancer cells to TNFa-induced apoptosis by inhibiting cytoprotective NF-kB activation
FEBS LETTERS 495/1-2 :66-70,2001

IFN gamma/TNF alpha synergism in MHC class II induction: effect of nicotinamide on MHC class II expression but not on islet-cell apoptosis
DIABETOLOGIA 45/3 :385-393,2002

Resistance of mitochondrial DNA-deficient cells to TRAIL: role of Bax in TRAIL-induced apoptosis
ONCOGENE 21/20 :3139-3148,2002

Identification and functional characterization of a novel mutation of hepatocyte nuclear factor-1 alpha gene in a Korean family with MODY3
DIABETOLOGIA 46/5 :721-727,2003

Pyruvate inhibits zinc-mediated pancreatic islet cell death and diabetes
DIABETOLOGIA 46/9 :1220-1227,2003

Resistance of mitochondrial DNA-depleted cells against cell death - Role of mitochondrial superoxide dismutase
JOURNAL OF BIOLOGICAL CHEMISTRY 279/9 :7512-7520,2004

Catecholamine cardiomyopathy associated with paraganglioma rescued by percutaneous cardiopulmonary support - Inverted takotsubo contractile pattern
CIRCULATION JOURNAL 71/12 :1993-1995,2007

NF-kappa B Activation in Hypothalamic Pro-opiomelanocortin Neurons Is Essential in Illness- and Leptin-induced Anorexia
The Journal of biological chemistry 285/13 :9706-9715,2010

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
NATURE MEDICINE 19/ :83-92,2013

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy
MOLECULAR CELL 51/ :618-631,2013

Acute Exercise Induces FGF21 Expression in Mice and in Healthy Humans
PLOS ONE 8/ :-,2013

Role of hypothalamic autophagy in the control of whole body energy balance
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS 14/ :377-386,2013

Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 440/1 :76-81,2013

Co-Transplantation of Bone Marrow-Derived Endothelial Progenitor Cells Improves Revascularization and Organization in Islet Grafts
AMERICAN JOURNAL OF TRANSPLANTATION 13/6 :1,429-1,440,2013

Diabetes-Free Survival in Patients Who Underwent Islet Autotransplantation After 50% to 60% Distal Partial Pancreatectomy for Benign Pancreatic Tumors
TRANSPLANTATION 95/11 :1,396-1,403,2013

Non-HDL-cholesterol/HDL-cholesterol is a better predictor of metabolic syndrome and insulin resistance than apolipoprotein B/apolipoprotein A1
INTERNATIONAL JOURNAL OF CARDIOLOGY 168/ :2,678-2,683,2013

Activin A, exendin-4, and glucose stimulate differentiation of human pancreatic ductal cells
JOURNAL OF ENDOCRINOLOGY 217/3 :241-252,2013

Immunotherapeutic Treatment of Autoimmune Diabetes
CRITICAL REVIEWS IN IMMUNOLOGY 33/3 :245-281,2013

Role of pancreatic beta-cell death and inflammation in diabetes
DIABETES OBESITY & METABOLISM 15/ :141-151,2013

Role of autophagy in the progression from obesity to diabetes and in the control of energy balance
ARCHIVES OF PHARMACAL RESEARCH 36/2 :223-229,2013

Microarray analysis of isolated human islet transcriptome in type 2 diabetes and the role of the ubiquitin-proteasome system in pancreatic beta cell dysfunction
MOLECULAR AND CELLULAR ENDOCRINOLOGY 367/1-2 :1-10,2013

PPAR-gamma Activation Increases Insulin Secretion through the Up-regulation of the Free Fatty Acid Receptor GPR40 in Pancreatic beta-Cells
PLOS ONE 8/1 :e50128-,2013

TLR3-triggered reactive oxygen species contribute to inflammatory responses by activating signal transducer and activator of transcription-1
JOURNAL OF IMMUNOLOGY 190/12 :6,368-6,377,2013

Germline mutation of Glu70Lys is highly frequent in Korean patients with von Hippel-Lindau (VHL) disease
JOURNAL OF HUMAN GENETICS 59/9 :488-493,2014

Autophagy-a key player in cellular and body metabolism
NATURE REVIEWS ENDOCRINOLOGY 10/6 :322-337,2014

Amyloidogenic peptide oligomer accumulation in autophagy-deficient beta cells induces diabetes
JOURNAL OF CLINICAL INVESTIGATION 124/8 :3,311-3,324,2014

Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes
NATURE COMMUNICATIONS 5/- :---,2014

The AMPK-PPARGC1A pathway is required for antimicrobial host defense through activation of autophagy
AUTOPHAGY 10/5 :785-802,2014

Proteasome Dysfunction Activates Autophagy and the Keap1-Nrf2 Pathway
JOURNAL OF BIOLOGICAL CHEMISTRY 289/36 :24,944-24,955,2014

An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice
GUT 63/ :727-735,2014

Autophagy as a crosstalk mediator of metabolic organs in regulation of energy metabolism
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS 15/ :11-20,2014

Chronic HMGCR/HMG-CoA Reductase Inhibitor Treatment Contributes to Dysglycemia by Upregulating Hepatic Gluconeogenesis through Autophagy Induction.
AUTOPHAGY 11/11 :2089-2101,2015

Gut Microbiota and Metabolic Disorders
Diabetes and Metabolism Journal 39/3 :198-203,2015

FGF21 as a mediator of adaptive responses to stress and metabolic benefits of anti-diabetic drugs
JOURNAL OF ENDOCRINOLOGY 226/1 :R1-R16,2015

Age-dependent gait abnormalities in mice lacking the Rnf170 gene linked to human autosomal-dominant sensory ataxia
HUMAN MOLECULAR GENETICS 24/25 :7196-7206,2015

Effect of mitochondrial stress on the systemic metabolism
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 1350/- :61-65,2015

New mechanisms of metformin action: Focusing on mitochondria and the gut
JOURNAL OF DIABETES INVESTIGATION 6/6 :600-609,2015

The association between glycemic variability and diabetic cardiovascular autonomic neuropathy in patients with type 2 diabetes
CARDIOVASCULAR DIABETOLOGY 14/70 :---,2015

Mutations in DDX58, which encodes RIG-I, cause atypical Singleton-Merten syndrome
AMERICAN JOURNAL OF HUMAN GENETICS 96/ :266-274,2015

Improved revascularization of islet grafts using an angiogenic monocyte subpopulation derived from spheroid culture of bone marrow mononuclear cells
AMERICAN JOURNAL OF TRANSPLANTATION 15/6 :1,543-1,554,2015

CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysis
SCIENTIFIC REPORTS 6/27938 :1-13,2016

Autophagy deficiency in myeloid cells increases susceptibility to obesity-induced diabetes and experimental colitis
AUTOPHAGY 12/8 :1,390-1,403,2016

Role of mitochondrial function in cell death and metabolism
FRONTIERS IN BIOSCIENCE-LANDMARK 21/ :1,233-1,244,2016

p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
NATURE COMMUNICATIONS 7/ :12,030-,2016

The orphan nuclear receptor erraγ regulates hepatic cb1 receptor-mediated fibroblast growth factor 21 gene expression
PLOS ONE 11/7 :e0159425-,2016

Secretagogin affects insulin secretion in pancreatic β-cells by regulating actin dynamics and focal adhesion.
BIOCHEMICAL JOURNAL 473/ :1,791-1,803,2016

Autophagy is a major regulator of beta cell insulin homeostasis
DIABETOLOGIA 59/ :1,480-1,491,2016

Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease
AUTOPHAGY 12/5 :784-800,2016

Mitochondria and the NLRP3 inflammasome: physiological and pathological relevance
ARCHIVES OF PHARMACAL RESEARCH 39/99 :1503-1518,2016

Autophagy induced by AXL receptor tyrosine kinase alleviates acute liver injury via inhibition of NLRP3 inflammasome activation in mice
AUTOPHAGY 12/12 :2,326-2,343,2016

Extracellular Vesicles as Messengers Between Hepatocytes and Macrophages in Nonalcoholic Steatohepatitis
GASTROENTEROLOGY 150/4 :815-818,2016

Ezetimibe ameliorates steatohepatitis via AMP activated protein kinase-TFEB-mediated mediated activation of autophagy and NLRP3 inflammasome inhibition
AUTOPHAGY 13/10 :1,767-1,781,2017

Alterations in gut microbiota and immunity by dietary fat
YONSEI MEDICAL JOURNAL 58/6 :1,083-1,091,2017

Obesogenic diet-induced gut barrier dysfunction and pathobiont expansion aggravate experimental colitis
PLOS ONE 12/11 :e0187515-,2017

A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes.
NATURE COMMUNICATIONS 9/1 :1,438-,2018

Growth differentiation factor 15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice
SCIENTIFIC REPORTS 8/1 :6,789-6,802,2018

The Role of Autophagy in Systemic Metabolism and Human-Type Diabetes
MOLECULES AND CELLS 41/1 :11-17,2018

Pathogenesis of Nonalcoholic Steatohepatitis and Hormone-Based Therapeutic Approaches
Frontiers in Endocrinology 9/ :485-499,2018

Nonsynonymous Variants in PAX4 and GLP1R Are Associated With Type 2 Diabetes in an East Asian Population
DIABETES 67/9 :1,892-1,902,2018

Atg7-dependent canonical autophagy regulates the degradation of aquaporin 2 in prolonged hypokalemia
SCIENTIFIC REPORTS 9/1 :3,021-,2019

Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway
CELL DEATH & DISEASE 10/2 :78-,2019

Autophagy in FOXD1 stroma-derived cells regulates renal fibrosis through TGF-β and NLRP3 inflammasome pathway
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 508/3 :965-972,2019

β-cell autophagy: Mechanism and role in β-cell dysfunction
MOLECULAR METABOLISM 27/ :S92-S103,2019

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