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Introduction

HOME > Hospitals > Severance Hospital > Departments > Clinical Pharmacology > Introduction

 
Clinical Pharmacology

Clinical pharmacology deals with combining the knowledge of basic pharmacology and clinical medicine in order to optimize the drug therapy in patients as well as to obtain the necessary knowledge and skills for the systematic planning and execution of clinical trials for new drug development. Department of Clinical Pharmacology in Severance Hospital has acquired specialists in clinical pharmacology who were trained at Hoechst, Germany, one of the largest pharmaceutical companies in the world and educated in graduate course in clinical pharmacology in University of Aberdeen, U.K. These clinical pharmacologists, who have their own specialties in other fields of medicine, such as medical oncology and neonatology, have the advantage of experience in clinical medicine, which can be put to use in the advancement of clinical pharmacology.

 

Clinical Trials for New Drug Development

Over 500 clinical trials have been carried out at Severance Hospital since 1986. Department of Clinical Pharmacology plays a crucial role in conducting early human trials involving pharmacokinetic and pharmacodynamic studies including bioequivalence tests as well as in giving consultational assistance to investigators for planning and systematic execution of clinical trials, including study design and analysis, based on the safety of trial participants and the scientifically sound methodology suggested by the GCP guidelines founded on Declaration of Helsinki. Offering reliable results through the systematic and efficient clinical trials, our department helps encourage and motivate the new drug development by domestic pharmaceutical companies and leads the advancement in the field of clinical pharmacology through accumulation of clinical as well as scientific information.

Education and Consultation for Optimization of Drug Therapy

Drug therapy is a must in the field of clinical medicine and for the most effective treatment drug therapy should be optimized for individual characteristics. Especially for drugs, such as cardiac glycosides or aminoglycoside antibiotics, which are effective for specific diseases but accompanied with toxicity, with narrow therapeutic ranges, without appropriate clinical parameters for its effectiveness, or with large interindividual variability, therapeutic drug monitoring is needed for the safe and effective use of the drug. Lectures in clinical pharmacology are given for medical students and house staff as well as provision of drug information. Our department also focuses on studies in clinical pharmacokinetics, pharmacogenetics, drug interaction, etc.

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