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HOME > Hospitals > Severance Hospital > Departments > Laboratory Medicine > Physician Directory

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SEUNG-TAE LEE
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Name SEUNG-TAE LEE
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Research

  • Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures
    NUCLEIC ACIDS RESEARCH 43/5 :2590-2602,2015
  • NOTCH2 missplicing can occur in relation to apoptosis
    BLOOD 126/14 :1731-1732,2015
  • Whole-genome fingerprint of the DNA methylome during human B cell differentiation
    NATURE GENETICS 47/7 :746-746,2015
  • A subset of CD45+/CD19-cells in bone marrow may be associated with clinical outcomes of patients with mantle cell lymphoma
    LEUKEMIA & LYMPHOMA 56/11 :3052-3057,2015
  • Genome-wide CpG island methylation and intergenic demethylation propensities vary among different tumor sites
    NUCLEIC ACIDS RESEARCH 44/3 :1105-1117,2016
  • 유전체 의학 시대를 맞이한 유전성 유방암-난소암 증후군 유전 검사의 임상적 함의: 임상의사가 바라본 전망
    Journal of Breast Disease 4/1 :1-9,2016
  • Frequency and Clinical Characteristics of Intrachromosomal Amplification of Chromosome 21 in Korean Childhood B-lineage Acute Lymphoblastic Leukemia
    ANNALS OF LABORATORY MEDICINE 36/5 :475-480,2016
  • Evaluation of an amplicon-based next-generation sequencing panel for detection of BRCA1 and BRCA2 genetic variants
    BREAST CANCER RESEARCH AND TREATMENT 158/3 :433-440,2016
  • Mutation profiling of 19 candidate genes in acute myeloid leukemia suggests significance of DNMT3A mutations
    ONCOTARGET 7/34 :54,825-54,837,2016
  • t(12;17)(p13;q12)/TAF15-ZNF384 Rearrangement in Acute Lymphoblastic Leukemia
    ANNALS OF LABORATORY MEDICINE 36/4 :396-398,2016
  • Detection of MYD88 L265P in patients with lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia and other B-cell non-Hodgkin lymphomas
    Blood Research 51/3 :181-186,2016
  • Usefulness of Flow Cytometric Analysis for Detecting Leptomeningeal Diseases in Non-Hodgkin Lymphoma
    ANNALS OF LABORATORY MEDICINE 36/3 :209-214,2016
  • Chronic Myeloid Leukemia With Rare Variant b2a3 (e13a3) BCR-ABL1 Fusion
    ANNALS OF LABORATORY MEDICINE 36/3 :287-289,2016
  • BRCA1 and BRCA2 mutation predictions using the BRCAPRO and Myriad models in Korean ovarian cancer patients
    GYNECOLOGIC ONCOLOGY 145/1 :137-141,2017
  • Comparison of Clinical Outcomes of BRCA1/2 Pathologic Mutation, Variants of Unknown Significance, or Wild Type Epithelial Ovarian Cancer Patients
    CANCER RESEARCH AND TREATMENT 49/2 :408-415,2017
  • Validation and Optimization of the Ion Torrent S5 XL Sequencer and Oncomine Workflow for BRCA1 and BRCA2 Genetic Testing
    ONCOTARGET 8/21 :34,858-34,866,2017
  • Telomere length in alcohol dependence: A role for impulsive choice and childhood maltreatment
    PSYCHONEUROENDOCRINOLOGY 83/ :72-78,2017
  • The effect of trauma and PTSD on telomere length: An exploratory study in people exposed to combat trauma
    SCIENTIFIC REPORTS 7/1 :4375-,2017
  • Quinidine Trial in a Patient with Epilepsy of Infancy with Migrating Focal Seizure and KCNT1 Mutation
    Journal of the Korean Child Neurology Society(대한소아신경학회지) 25/3 :169-173,2017
  • Identification of a Novel BRCA1 Pathogenic Mutation in Korean Patients Following Reclassification of BRCA1 and BRCA2 Variants According to the ACMG Standards and Guidelines Using Relevant Ethnic Controls
    CANCER RESEARCH AND TREATMENT 49/4 :1,012-1,021,2017
  • Diagnostic application of clinical exome sequencing in Leber congenital amaurosis
    MOLECULAR VISION 23/ :649-659,2017
  • Accuracy of Next-Generation Sequencing for Molecular Diagnosis in Patients With Infantile Nystagmus Syndrome
    JAMA OPHTHALMOLOGY 135/12 :1376-1385,2017
  • Mowat-Wilson syndrome presenting with fever-associated seizures.
    EPILEPTIC DISORDERS 19/4 :481-485,2017
  • Detection of Immunoglobulin Heavy Chain Gene Clonality by Next-Generation Sequencing for Minimal Residual Disease Monitoring in B-Lymphoblastic Leukemia
    ANNALS OF LABORATORY MEDICINE 37/4 :331-335,2017
  • Efficacy of Stiripentol in Dravet Syndrome with or without SCN1A Mutations
    JOURNAL OF CLINICAL NEUROLOGY 14/1 :22-28,2018
  • Application of Multiplex Ligation-Dependent Probe Amplification Assay for Genotyping Major Blood Group Systems Including DEL Variants in the D-Negative Korean Population
    ANNALS OF LABORATORY MEDICINE 38/1 :32-38,2018
  • Variants of cancer susceptibility genes in Korean BRCA1/2 mutation-negative patients with high risk for hereditary breast cancer
    BMC CANCER 18/1 :83-90,2018
  • Efficient strategy for the molecular diagnosis of intractable early-onset epilepsy using targeted gene sequencing
    BMC MEDICAL GENOMICS 11/1 :6-,2018
  • Targeted gene panel and genotype-phenotype correlation in children with developmental and epileptic encephalopathy
    EPILEPSY RESEARCH 141/ :48-55,2018
  • Detection of Germline Mutations in Patients with Epithelial Ovarian Cancer Using Multi-Gene Panels: Beyond BRCA1/2.
    CANCER RESEARCH AND TREATMENT 50/3 :917-925,2018
  • The efficacy of ketogenic diet for specific genetic mutation in developmental and epileptic encephalopathy
    FRONTIERS IN NEUROLOGY 9/JUL :530-538,2018
  • Difference in Risk of Breast and Ovarian Cancer According to Putative Functional Domain Regions in Korean BRCA1/2 Mutation Carriers.
    CLINICAL BREAST CANCER 18/5 :362-373,2018
  • A patient with B-cell acute lymphoblastic leukemia with PAX5-ETV6 rearrangement with dic(9;12)(p13;p13) identified by chromosomal microarray
    ANNALS OF HEMATOLOGY 97/8 :1,505-1,507,2018
  • Deletion of 20p13 and Duplication of 20p13p12.3 in a Patient with Delayed Speech and Development
    ANNALS OF LABORATORY MEDICINE 38/1 :77-79,2018
  • SNP-based next-generation sequencing reveals low-level mixed chimerism after allogeneic hematopoietic stem cell transplantation
    ANNALS OF HEMATOLOGY 97/9 :1,731-1,734,2018
  • Early Diagnosis of KBG Syndrome Using Diagnostic Exome Sequencing
    Journal of the Korean Child Neurology Society(대한소아신경학회지) 26/4 :272-275,2018
  • Distinct Clinical Courses of Epithelial Ovarian Cancer with Mutations in BRCA1 5’ and 3’ Exons
    ANTICANCER RESEARCH 38/12 :6,947-6,953,2018
  • FLT3 Internal Tandem Duplication in Patients With Acute Myeloid Leukemia Is Readily Detectable in a Single Next-Generation Sequencing Assay Using the Pindel Algorithm
    ANNALS OF LABORATORY MEDICINE 39/3 :327-329,2019
  • Clinical Evaluation of Massively Parallel RNA Sequencing for Detecting Recurrent Gene Fusions in Hematologic Malignancies
    JOURNAL OF MOLECULAR DIAGNOSTICS 21/1 :163-170,2019
  • Systematic evaluation of gene variants linked to hearing loss based on allele frequency threshold and filtering allele frequency
    SCIENTIFIC REPORTS 9/1 :4583-,2019
  • The TECTA mutation R1890C is identified as one of the causes of genetic hearing loss: a case report
    BMC MEDICAL GENETICS 20/1 :57-57,2019
  • Targeted next generation sequencing can serve as an alternative to conventional tests in myeloid neoplasms
    PLOS ONE 14/3 :e0212228-,2019
  • A Child With Lymphangioma Due to Somatic Mutation in PIK3CA Successfully Treated With Everolimus
    PEDIATRIC NEUROLOGY 91/ :65-67,2019
  • Somatic mosaic truncating mutations of PPM1D in blood can result from expansion of a mutant clone under selective pressure of chemotherapy
    PLOS ONE 14/6 :e0217521-,2019
  • Next-generation sequencing with comprehensive bioinformatics analysis facilitates somatic mosaic APC gene mutation detection in patients with familial adenomatous polyposis
    BMC MEDICAL GENOMICS 12/1 :103-,2019
  • A Somatic p.Phe29del Mutation of Connexin 26 (GJB2) Manifesting as Acantholytic Dyskeratotic Epidermal Nevus
    JAMA DERMATOLOGY 155/5 :633-635,2019
  • Diagnostic challenge: Primary bone marrow diffuse large B-cell lymphoma mimicking systemic autoimmune disorders
    Laboratory Medicine Online 9/4 :242-245,2019
  • Proband-Only Clinical Exome Sequencing for Neurodevelopmental Disabilities
    PEDIATRIC NEUROLOGY 99/ :47-54,2019
  • Clinical Implementation of Targeted Gene Sequencing for Malformation of Cortical Development
    PEDIATRIC NEUROLOGY 99/ :47-54,2019
  • Genetic and clinical features of SCN8A developmental and epileptic encephalopathy
    EPILEPSY RESEARCH 158/1 :e106222-,2019
  • Mutant Thr95Ile Transthyretin-Related Cardiac Amyloidosis With Polyneuropathy
    CIRCULATION JOURNAL 83/11 :2,328-2,328,2019

Professional Experience

2002-2003 서울아산병원 Intern 수료
2004-2008 삼성서울병원 진단검사의학과 Resident 수료
2008-2015 삼성서울병원 진단검사의학과 임상강사, 임상전임강사, 진료부교수
2011-2012 University of California, San Francisco 연수
2015-현재 연세대학교 의과대학 진단검사의학교실 임상부교수

Membership

대한진단검사의학회 회원
대한혈액학회 회원
한국유전체학회 회원

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