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Physician Directory

HOME > Hospitals > Severance Hospital > Departments > Neurosurgery > Physician Directory

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Seok-Gu Kang
doctor's information
Name Seok-Gu Kang
Department
Major Neurosurgery/ Brain Tumor, Neuro-oncology, Head Trauma
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Research

  • Staged Decompression of Chiari I Malformation Associated with Basilar Invagination. Kang SG, Jeun SS, Lee IW, Park CK, Hong YK, Kim MC, Kang JK: J Korean Neurosurg Soc 1998:27(10):1429-1433
  • Influence of Brain edema on the Antiischemic Effect of D-CPPene in Rat Focal Cerebral Infarction. Kang SG, Park CK, Kang JK: J Korean Neurosurg Soc 1999:28(8):1075-1081
  • Effect of Brain Oedema in the Measurement of Ischaemic Brain Damage in Focal Cerebral Infarction. Park CK, Kang SG. Acta Neurochir Suppl. 2000;76:269-271.
  • Lymphokine Activated Killer Cells from Umbilical Cord Blood Show Higher Antitumor Effect against Anaplastic Astrocytoma Cell Line (U87) and Medulloblastoma Cell Line (TE671) than Lymphokine Activated Killer Cells from Peripheral Blood. Kang SG, Ryu CH, Jeun SS, Park CK, Shin HJ, Kim JH, Kim MC, Kang JK. Childs Nerv Syst. 2004;20(3):154-162.
  • Surgical Approaches of Lateral Ventricle Tumors. Kang SG, Park K: J Korean Brain Tumor Soc 2004:3(2):82-87
  • Clinical and Radiological Prognostic Factors of Anaplastic Oligodendroglioma Treated by Combined Therapy. Neurol Med Chir (Tokyo). 2005 45(5):232-238; discussion 238-239.
  • Cytotoxicity of rat marrow stromal cells against malignant glioma cells. Childs Nerv Syst. 2005 21(7):528-538.
  • Interpretation of Wada Test in Anterior Temporal Lobectomy. J of The Kor Soc of Ster and Func Neurosur 2005:1(1):20-24
  • Combination celecoxib and temozolomide in C6 rat glioma orthotopic model. Oncol Rep. 2006 Jan;15(1):7-13.
  • Coexisting intracranial meningeal melanocytoma, dermoid tumor, and Dandy-Walker cyst in a patient with neurocutaneous melanosis. J Neurosurg. 2006 104(3):444-447.
  • Merlin inhibits growth hormone-regulated Raf-ERKs pathways by binding to Grb2 protein. Biochem Biophys Res Commun. 2006 24;340(4):1151-1157.
  • Effects of Hydroxycholroquine Co-administrated with Chemotherapeutic Agents on Malignant Glioma Cell Lines: in vitro Study. J Korean Neurosurg Soc. 2006 39(4):317-317 letter to editor
  • Multiple stem cell traits of expanded rat bone marrow stromal cells. Exp Neurol. 2006 199(2):416-26.
  • Diagnostic method for differentiating external hydrocephalus from simple subdural hygroma. J Neurosurg. 2006 105(1):65-70.
  • Combined direct anastomosis and encephaloduroarteriogaleosynangiosis using inverted superficial temporal artery-galeal flap and superficial temporal artery-galeal pedicle in adult moyamoya disease Surg Neurol. 2006 66(4):389-394; discussion 395.
  • Clinical images: Myositis ossificans of the upper extremity. Arthritis Rheum. 2007 56(7):2454.
  • Tethered cord syndrome; Surgical indication, technique and outcome. J Korean Neurosurg Soc. 2007 42(2):77-82.
  • Sudden cortical blindness in an adult with moyamoya disease. Surg Neurol. 2007 67(3):303-307.
  • Simple excision and periosteal reattachment for the treatment of calcified cephalhematoma - Technical note. J Neurosurg. 2007 106(2 Suppl):162-4.
  • Pituitary abscess in a pregnant woman. J Clin Neurosci. 2007 14(11):1135-1139.
  • Provisional experiences about KSPNO-G051, KSPNO-G052 protocols for the treatment of central nervous system germ cell tumors. J Korean Soc Pediatric Neurosurg 2007 4(1):57-66
  • Surgical results in pediatric moyamoya disease: Angiographic revascularization and the clinical results. Clin Neurol Neurosurg. 2007 109(2):125-31.
  • Clinical and radiographie results of unilateral transpedicular balloon kyphoplasty for the treatment of osteoporotic vertebral compression fractures. Acta Neurochir Suppl. 2008;101:157-60.
  • Cranioplasty effect on the cerebral hemodynamics and cardiac function. Acta Neurochir Suppl. 2008;102:15-20.
  • Cytotoxicity of human umbilical cord blood-derived mesenchymal stem cells against human malignant glioma cells. Childs Nerv Syst. 2008 24(3):293-302.
  • Comparison of the effect of decompressive craniectomy on different neurosurgical diseases. Acta Neurochir (Wien). 2009 151(1):21-30.
  • Risk Factors and Surgical Treatment for Symptomatic Adjacent S
  • C-Jun N-terminal kinase has a pivotal role in the maintenance of self-renewal and tumorigenicity in glioma stem-like cells
    ONCOGENE 31/44 :4655-4666,2012
  • Isolation of glioma cancer stem cells in relation to histological grades in glioma specimens.
    CHILDS NERVOUS SYSTEM 29/2 :217-229,2013
  • Postoperative nasal symptoms associated with an endoscopic endonasal transsphenoidal approach
    EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY 270/4 :1355-1359,2013
  • Changes in the biological characteristics of glioma cancer stem cells after serial in vivo subtransplantation.
    CHILDS NERVOUS SYSTEM 29/1 :55-64,2013
  • Existence of glioma stroma mesenchymal stemlike cells in Korean glioma specimens
    CHILDS NERVOUS SYSTEM 29/4 :549-563,2013
  • Increased in vivo angiogenic effect of glioma stromal mesenchymal stem-like cells on glioma cancer stem cells from patients with glioblastoma
    INTERNATIONAL JOURNAL OF ONCOLOGY 42/5 :1754-1762,2013
  • A novel 2-pyrone derivative, BHP, impedes oncogenic KRAS-driven malignant progression in breast cancer
    CANCER LETTERS 337/1 :49-57,2013
  • Isolation of mesenchymal stem-like cells in meningioma specimens
    INTERNATIONAL JOURNAL OF ONCOLOGY 43/4 :1260-1268,2013
  • Bilateral Nasoseptal Flaps for Endoscopic Endonasal Transsphenoidal Approach
    JOURNAL OF CRANIOFACIAL SURGERY 24/ :1569-1572,2013
  • Fractionated radiation-induced nitric oxide promotes expansion of glioma stem-like cells
    CANCER SCIENCE 104/ :1172-1177,2013
  • Isolation of tumor spheres and mesenchymal stem-like cells from a single primitive neuroectodermal tumor specimen
    CHILDS NERVOUS SYSTEM 29/12 :2229-2239,2013
  • Bilateral modified nasoseptal "rescue" flaps in the endoscopic endonasal transsphenoidal approach
    LARYNGOSCOPE 123/11 :2605-2609,2013
  • Isolation of Mesenchymal Stem-like Cells from a Pituitary Adenoma Specimen
    대한의생명과학회지 19/4 :295-302,2013
  • Temozolomide salvage chemotherapy for recurrent anaplastic oligodendroglioma and oligo-astrocytoma
    JOURNAL OF KOREAN NEUROSURGICAL SOCIETY 54/6 :489-495,2013
  • Study of freshly excised brain tissues using terahertz imaging
    BIOMEDICAL OPTICS EXPRESS 5/8 :2837-2842,2014
  • Role of the superior turbinate when performing endoscopic endonasal transsphenoidal approach
    FOLIA MORPHOLOGICA 73/1 :73-78,2014
  • Prognostic value of glioma cancer stem cell isolation in survival of primary glioblastoma patients
    STEM CELLS INTERNATIONAL 2014/0 :0-0,2014
  • Atypical location and clinical behavior of a subset of intracranial germ cell tumors in children younger than 3 years of age
    JOURNAL OF NEUROSURGERY-PEDIATRICS 14/4 :348-355,2014
  • Potential use of glioblastoma tumorsphere: Clinical credentialing
    ARCHIVES OF PHARMACAL RESEARCH 38/3 :402-407,2015
  • T2 - and T*2-weighted MRI of rat glioma using polysorbate-coated magnetic nanocrystals as a blood-pool contrast agent
    RSC ADVANCES 5/25 :19708-19714,2015
  • Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy
    NATURE MEDICINE 21/4 :395-400,2015
  • Primary diffuse leptomeningeal gliosarcoma
    Brain Tumor Reserach and Treatment 3/1 :34-38,2015
  • The Added Prognostic Value of Preoperative Dynamic Contrast-Enhanced MRI Histogram Analysis in Patients with Glioblastoma: Analysis of Overall and Progression-Free Survival
    AMERICAN JOURNAL OF NEURORADIOLOGY 36/12 :2235-2241,2015
  • Mesenchymal Stem Cells Isolated From Human Gliomas Increase Proliferation and Maintain Stemness of Glioma Stem Cells Through the IL-6/gp130/STAT3 Pathway
    STEM CELLS 33/8 :2400-2415,2015
  • Pseudoprogression in glioblastoma patients: the impact of extent of resection
    JOURNAL OF NEURO-ONCOLOGY 126/3 :559-566,2016
  • Tumor mesenchymal stem-like cell as a prognostic marker in primary glioblastoma
    STEM CELLS INTERNATIONAL 2016/Arti :1-7,2016
  • PKCδ activated by c-MET enhances infiltration of human glioblastoma cells through NOTCH2 signaling
    ONCOTARGET 7/4 :4890-4902,2016
  • Strategies of mesenchymal invasion of patient-derived brain tumors: Microenvironmental adaptation.
    SCIENTIFIC REPORTS 25/6 :24912-24912,2016
  • Current and future perspectives in craniosynostosis.
    JOURNAL OF KOREAN NEUROSURGICAL SOCIETY 59/3 :247-249,2016
  • Failure of a patient-derived xenograft for brain tumor model prepared by implantation of tissue fragments
    CANCER CELL INTERNATIONAL 16/43 :1-6,2016
  • Isolation and characterization of tumorspheres from a recurrent pineoblastoma patient: Feasibility of a patient-derived xenograft.
    INTERNATIONAL JOURNAL OF ONCOLOGY 49/ :567-578,2016
  • Histopathological implications of ventricle wall 5-aminolevulinic acid-induced fluorescence in the absence of tumor involvement on magnetic resonance images
    ONCOLOGY REPORTS 36/2 :837-844,2016
  • A polyethylene glycol-based hydrogel as macroporous scaffold for tumorsphere formation of glioblastoma multiforme
    JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY 39/ :10-15,2016
  • Incremental Prognostic Value of ADC Histogram Analysis over MGMT Promoter Methylation Status in Patients with Glioblastoma
    RADIOLOGY 281/1 :175-184,2016
  • Inhibiting stemness and invasive properties of glioblastoma tumorsphere by combined treatment with temozolomide and a newly designed biguanide (HL156A)
    ONCOTARGET 7/40 :65,643-65,659,2016
  • Terahertz reflectometry imaging for low and high grade gliomas
    SCIENTIFIC REPORTS 6/36,040 :1-9,2016
  • Success of tumorsphere isolation from WHO grade IV gliomas does not correlate with the weight of fresh tumor specimens: an immunohistochemical characterization of tumorsphere differentiation
    CANCER CELL INTERNATIONAL 16/75 :1-7,2016
  • Hemangiopericytomas in the Central Nervous System: A Multicenter Study of Korean Cases with Validation of the Usage of STAT6 Immunohistochemistry for Diagnosis of Disease
    ANNALS OF SURGICAL ONCOLOGY 23/ :S954-S961,2016
  • Tumor-associated mesenchymal stem-like cells provide extracellular signaling cue for invasiveness of glioblastoma cells
    ONCOTARGET 8/1 :1,438-1,448,2017
  • Concurrent Chemoradiotherapy with Temozolomide Followed by Adjuvant Temozolomide for Newly Diagnosed Glioblastoma Patients: A Retrospective Multicenter Observation Study in Korea
    CANCER RESEARCH AND TREATMENT 49/1 :193-203,2017
  • Inhibition of glioblastoma tumorspheres by combined treatment with 2-deoxyglucose and metformin
    NEURO-ONCOLOGY 19/2 :197-207,2017
  • Primary central nervous system lymphoma and atypical glioblastoma: differentiation using the initial area under the curve derived from dynamic contrast-enhanced MR and the apparent diffusion coefficient
    EUROPEAN RADIOLOGY 27/4 :1,344-1,351,2017
  • Amide proton transfer imaging to discriminate between low- and high-grade gliomas: added value to apparent diffusion coefficient and relative cerebral blood volume
    EUROPEAN RADIOLOGY 27/8 :3,181-3,189,2017
  • Spontaneous Acute Subdural Hemorrhage in a Patient with a Tick Borne Bunyavirus-Induced Severe Fever with Thrombocytopenia Syndrome
    Korean Journal of neurotrauma 13/1 :57-60,2017
  • Effects of Postoperative Radiotherapy on Leptomeningeal Carcinomatosis or Dural Metastasis after Resection of Brain Metastases in Breast Cancer Patients
    CANCER RESEARCH AND TREATMENT 49/3 :748-758,2017
  • The initial area under the curve derived from dynamic contrast-enhanced MRI improves prognosis prediction in glioblastoma with unmethylated MGMT promoter
    AMERICAN JOURNAL OF NEURORADIOLOGY 38/8 :1,528-1,535,2017
  • Effectiveness of navigation-guided cyst aspiration before resection of large cystic brain tumors: a proof of concept for more radical surgery
    ACTA NEUROCHIRURGICA 159/10 :1,947-1,954,2017
  • Elderly patients with newly diagnosed glioblastoma: can preoperative imaging descriptors improve the predictive power of a survival model?
    JOURNAL OF NEURO-ONCOLOGY 134/2 :423-431,2017
  • Long-term outcomes of concomitant chemoradiotherapy with temozolomide for newly diagnosed glioblastoma patients A single-center analysis
    MEDICINE 96/27 :e7422-,2017
  • Regulation of cAMP and GSK3 signaling pathways contributes to the neuronal conversion of glioma
    PLOS ONE 12/11 :e0178881-,2017
  • Amide proton transfer imaging for differentiation of benign and atypical meningiomas
    EUROPEAN RADIOLOGY 28/1 :331-339,2018
  • Prediction of IDH1-Mutation and 1p/19q-Codeletion Status Using Preoperative MR Imaging Phenotypes in Lower Grade Gliomas
    AMERICAN JOURNAL OF NEURORADIOLOGY 39/1 :37-42,2018
  • The mode and dynamics of glioblastoma cell invasion into a decellularized tissue-derived extracellular matrix-based three-dimensional tumor model
    SCIENTIFIC REPORTS 8/1 :4608-1-4608-12,2018
  • Synthesis and structure-activity relationships of quinolinone and quinoline-based P2X7 receptor antagonists and their anti-sphere formation activities in glioblastoma cells
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 151/ :462-481,2018
  • Whole-Tumor Histogram and Texture Analyses of DTI for Evaluation of IDH1-Mutation and 1p/19q-Codeletion Status in World Health Organization Grade II Gliomas
    AMERICAN JOURNAL OF NEURORADIOLOGY 39/4 :693-698,2018
  • Force-mediated proinvasive matrix remodeling driven by tumor-associated mesenchymal stem-like cells in glioblastoma
    BMB REPORTS 51/4 :182-187,2018
  • Regulation of bioenergetics through dual inhibition of aldehyde dehydrogenase and mitochondrial complex I suppresses glioblastoma tumorspheres
    NEURO-ONCOLOGY 20/7 :954-965,2018
  • Proinvasive extracellular matrix remodeling in tumor microenvironment in response to radiation
    ONCOGENE 37/24 :3,317-3,328,2018
  • Human glioblastoma arises from subventricular zone cells with low-level driver mutations.
    NATURE 560/ :243-247,2018
  • Primary central nervous system lymphoma and atypical glioblastoma: Differentiation using radiomics approach
    EUROPEAN RADIOLOGY 28/9 :3,832-3,839,2018
  • Farnesyl diphosphate synthase is important for the maintenance of glioblastoma stemness
    EXPERIMENTAL AND MOLECULAR MEDICINE 50/ :137-149,2018
  • Pheochromocytoma with Brain Metastasis: A Extremely Rare Case in Worldwide
    Brain Tumor Reserach and Treatment 6/2 :101-104,2018
  • Association analysis of RTEL1 variants with risk of adult gliomas in a Korean population
    PLOS ONE 13/11 :207,660-207,669,2018
  • Radiomic MRI phenotyping of glioblastoma: improving survival prediction
    RADIOLOGY 289/3 :797-806,2018
  • MerTK mediates STAT3-KRAS/SRC-signaling axis for glioma stem cell maintenance
    ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY 46/s2 :s87-s95,2018
  • Effect of combined anti-PD-1 and temozolomide therapy in glioblastoma
    ONCOIMMUNOLOGY 8/1 :e1525243-e1525253,2019
  • Clinical predictors of radiation-induced lymphopenia in patients receiving chemoradiation for glioblastoma: clinical usefulness of intensity-modulated radiotherapy in the immuno-oncology era
    RADIATION ONCOLOGY 14/1 :51-60,2019
  • Solitary fibrous tumor/hemangiopericytoma: treatment results based on the 2016 WHO classification
    JOURNAL OF NEUROSURGERY 130/2 :418-425,2019
  • Immune checkpoint inhibitor-induced reinvigoration of tumor-infiltrating CD8+ T cells is determined by their differentiation status in glioblastoma
    CLINICAL CANCER RESEARCH 25/8 :2,549-2,559,2019
  • Targeted next-generation sequencing panel (TruSight Tumor 170) in diffuse glioma: a single institutional experience of 135 cases
    JOURNAL OF NEURO-ONCOLOGY 142/3 :445-454,2019
  • Combined treatment with 2′-hydroxycinnamaldehyde and temozolomide suppresses glioblastoma tumorspheres by decreasing stemness and invasiveness
    JOURNAL OF NEURO-ONCOLOGY 143/1 :69-77,2019
  • Relevance of a TCGA-derived Glioblastoma Subtype Gene-Classifier among Patient Populations
    SCIENTIFIC REPORTS 9/1 :7,442-7,442,2019
  • The Korean Society for Neuro-Oncology (KSNO) guideline for glioblastomas: version 2018.01
    Brain Tumor Reserach and Treatment 7/1 :1-9,2019
  • Re-evaluation of the diagnostic performance of 11C-methionine PET/CT according to the 2016 WHO classification of cerebral gliomas
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 46/8 :1,678-1,684,2019
  • Transcriptome profiling-based identification of prognostic subtypes and muti-omics signatures of glioblastoma
    SCIENTIFIC REPORTS 9/1 :e10555-,2019
  • Gossypol Suppresses Growth of Temozolomide-Resistant Glioblastoma Tumor Spheres
    Biomolecules 9/10 :E595-,2019

Professional Experience

Surgical Neuro-Oncology
Glioma
Metastatic brain tumor
Meningioma
Translational research for brain tumor

Membership

Society for Neuro-Oncology
European Association of Neuro-Oncology
British Neuro-Oncology Society
Korean Neurosurgical Society
Korean Society for Neuro-Oncology
Korean Brain Tumor Society

Academic Career

Internship : 1995-1996, St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.
Residency : 1996-2000, Neurosurgery, St. Mary's Hospital, The Catholic University of Korea Colleage of Medicine, Seoul, Korea.
Military service: 2000-2001, The Armed Forced Gangnung Hospital (Captain)
2001-2003, Medical Bureau, Presidential Security Service (Captain)
Fellowship : 2003-2004 Neurosurgery (Brain tumor), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
2004-2005 Neurosurgery (Pediatric Neurosurgery), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
2007-2009 Post-doc fellow, Brain Tumor Center, Neurosurgery, M. D. Anderson Cancer Center, Houston, Texas, USA
Academic Appointments
: March, 2005 Assistant professor of Neurosurgery, The Catholic University of Korea College of Medicine, Uijeongbu St. Mary's Hospital, Uijeongbu, Korea
: April/2009 Associate professor of Neurosurgery, The Catholic University of Korea College of Medicine, Uijeongbu St. Mary's Hospital, Uijeongbu, Korea
: March/2010 Associate professor of Neurosurgery, The Catholic University of Korea College of Medicine, Seoul St. Mary's Hospital, Seoul, Korea

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